Review Article
Cleidocranial dysplasia. A molecular and clinical review
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Andrea AvendañoORCID, Francisco Cammarata-ScalisiORCID, Mochamad Fahlevi RizalORCID, Sarworini Bagio BudiardjoORCID, Margaretha SuharsiniORCID, Eva FauziahORCID, Nicola Maria GrandeORCID, Leonzio FortunatoORCID, Gianluca PlotinoORCID, İzzet YavuzORCID, Michele CalleaORCID
Cite
Avendaño A, Cammarata-Scalisi F, Rizal MF, et al. Cleidocranial dysplasia. A molecular and clinical review. Int Dent Res. 2018;8(1):35-38. https://doi.org/10.5577/intdentres.2018.vol8.no1.6
- eISSN
- 2146-1767
- Submitted
- 20 January 2018
- Accepted
- 12 February 2018
- Published
- 30 April 2018
- Pages
- 35-38
Abstract
Cleidocranial dysplasia (CCD) is a rare autosomal dominant disorder characterized by skeletal and dental abnormalities primarily, short stature, aplasia or hypoplasia of clavicles, open fontanelles and supernumerary teeth. Heterozygous mutations of the runt related transcription factor 2 (RUNX2) gene have been found in approximately 60-70% of cases leaving a large number of cases with no defined genetic cause which led us to delve into molecular mechanisms underlying CCD and thus to detect potential target genes to be explored in these patients. In this review we also highlight very broadly the phenotypic characteristics of previously reported patients with CCD.
How to cite this article: Avendaño A, Cammarata-Scalisi F, Rizal MF, Budiardjo SB, Suharsini M, Fauziah E, Grande NM, Fortunato L, Plotino G, Yavuz I, Callea M. Cleidocranial dysplasia. A molecular and clinical review. Int Dent Res 2018;8(1):35-38.
Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.
Keywords
© 2018 The Author(s). Published by International Dental Research.