Biomechanic and biochemical analysis of the effects of local Ankaferd Blood Stopper® application on osseointegration of titanium implants

Authors

DOI:

https://doi.org/10.5577/intdentres.2022.vol12.no1.5

Keywords:

Ankaferd Blood Stopper, osseintegration, bone implant contact, bone formation, biomechanic

Abstract

Aim: Investigations into Ankaferd Blood Stopper® (ABS) on bone healing have revealed positive bone regeneration effects. The exact mechanism of this positive bone tissue metabolism effect is unknown. This study’s aim is a biomechanic and biochemical investigation of the effects of local ABS application on the osseointegration of titanium implants.

Methodology: Sprague Dawley rats were divided into four groups of ten rats each. The control group (n=20) received no treatment during the experimental period, while the ABS group (n=20) had ABS applied locally during the surgical application of the titanium implant before insertion into the bone sockets. After 2 (controls n=10 and ABS n=10) and 4 weeks (controls n=10 and ABS n=10) experimental periods, the rats were sacrificed and implants with surrounding bone tissues were removed for reverse torque analysis (Newton), blood sample collection, and biochemical analysis.

Results: The biomechanic bone implant contact ratio detected was higher in week 4 than in week 2 in the ABS group (p<0, 05). Lower phosphor levels were detected in the ABS group than in the 4-week controls (p<0, 05).

Conclusion: According to the biomechanical parameters, ABS is more effective after four weeks than after two weeks when locally applied.

 

How to cite this article:

Özcan EC, Gül M, Tanık A, Yıldırım TT, Özkan M, Bozoğlan A, Özdemir HE, Dündar S. Biomechanic and biochemical analysis of the effects of local Ankaferd Blood Stopper® application on osseointegration of titanium implants. Int Dent Res 2022;12(1):27-33. https://doi.org/10.5577/intdentres.2022.vol12.no1.5

 

Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.

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Published

30-04-2022
CITATION

How to Cite

Özcan, E. C., Gül, M., Tanık, A., Yıldırım, T. T., Özkan, M., Bozoğlan, A., Özdemir, H. E., & Dündar, S. (2022). Biomechanic and biochemical analysis of the effects of local Ankaferd Blood Stopper® application on osseointegration of titanium implants. International Dental Research, 12(1), 27–33. https://doi.org/10.5577/intdentres.2022.vol12.no1.5