Original Article
Biomechanic and biochemical analysis of the effects of local Ankaferd Blood Stopper® application on osseointegration of titanium implants
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Erhan Cahit ÖzcanORCID, Mehmet GülORCID, Abdulsamet TanıkORCID, Tuba Talo YıldırımORCID, Mustafa ÖzkanORCID, Alihan BozoğlanORCID, Hasan Emre ÖzdemirORCID, Serkan DündarORCID
Cite
Özcan EC, Gül M, Tanık A, et al. Biomechanic and biochemical analysis of the effects of local Ankaferd Blood Stopper® application on osseointegration of titanium implants. Int Dent Res. 2022;12(1):27-33. https://doi.org/10.5577/intdentres.2022.vol12.no1.5
- eISSN
- 2146-1767
- Submitted
- 8 March 2022
- Accepted
- 10 August 2022
- Published
- 30 April 2022
- Pages
- 27-33
Abstract
Aim: Investigations into Ankaferd Blood Stopper® (ABS) on bone healing have revealed positive bone regeneration effects. The exact mechanism of this positive bone tissue metabolism effect is unknown. This study’s aim is a biomechanic and biochemical investigation of the effects of local ABS application on the osseointegration of titanium implants.
Methodology: Sprague Dawley rats were divided into four groups of ten rats each. The control group (n=20) received no treatment during the experimental period, while the ABS group (n=20) had ABS applied locally during the surgical application of the titanium implant before insertion into the bone sockets. After 2 (controls n=10 and ABS n=10) and 4 weeks (controls n=10 and ABS n=10) experimental periods, the rats were sacrificed and implants with surrounding bone tissues were removed for reverse torque analysis (Newton), blood sample collection, and biochemical analysis.
Results: The biomechanic bone implant contact ratio detected was higher in week 4 than in week 2 in the ABS group (p<0, 05). Lower phosphor levels were detected in the ABS group than in the 4-week controls (p<0, 05).
Conclusion: According to the biomechanical parameters, ABS is more effective after four weeks than after two weeks when locally applied.
How to cite this article:
Özcan EC, Gül M, Tanık A, Yıldırım TT, Özkan M, Bozoğlan A, Özdemir HE, Dündar S. Biomechanic and biochemical analysis of the effects of local Ankaferd Blood Stopper® application on osseointegration of titanium implants. Int Dent Res 2022;12(1):27-33. https://doi.org/10.5577/intdentres.2022.vol12.no1.5
Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.
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© 2022 The Author(s). Published by International Dental Research.