Biochemical marker levels in peri-implant crevicular fluid of completely edentulous patients with two implant-supported mandibular overdentures before and 6 months after loading: Prospective clinical trial

Abstract

Aim: The aim of this study was to determine the levels of biochemical markers detected in the peri-implant crevicular fluid (PICF) before and 6 months after loading in completely edentulous patients with two implant-supported mandibular overdentures and to correlate them with clinical parameters.

Methodology: Two implants were applied to the mandibular canine region of the 20 completely edentulous and systemically healthy patients (11 females, 9 males) with conventional 2-stage surgery. PICF samples of the participants were collected before and 6 months after prosthetic loading, and clinical parameters—including modified plaque index (MPI), gingival index (GI), bleeding on probing (BoP), probing pocket depth (PPD), and keratinized gingival width (KGW)—were recorded. Interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), matrix metalloproteinase-8 (MMP-8), and aspartate aminotransferase (AST) levels were examined in PICF samples via enzyme-linked immunosorbent assay (ELISA). The SPSS package program was used to statistically analyze the data.

Results: The average age of the participants was 57.05 ± 9.82 years. Although a decrease was observed in all clinical parameters after prosthetic loading compared to baseline levels, this decrease was not considered statistically significant (p>0.05). PICF volume showed a statistically significant decrease from baseline to 6 months (p<0.05). The decreases observed at 6th month values in all of the biochemical markers examined were not found to be statistically significant, similar to the clinical parameters (p>0.05).

Conclusion: Within the limits of this study, the PICF marker levels and clinical parameters determined following osseointegration and 6 months after prosthetic loading are similar. This suggests that the studied sample has prosthetic restorations that contribute positively to the tissue maturation process and apply ideal forces to the tissue. More comprehensive studies are recommended to understand the tissue healing process after implant treatment.

How to cite this article: Ayhan Alkan E, Yaylı Alpaslan NZ. Biochemical marker levels in peri-implant crevicular fluid of completely edentulous patients with two implant-supported mandibular overdentures before and 6 months after loading: Prospective clinical trial. Int Dent Res 2021;11(Suppl.1):160-6. https://doi.org/10.5577/intdentres.2021.vol11.suppl1.24

Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.