Oral Surgery In Severe Thrombocytopaenia Patients: A Case-Control Comparison of Platelet Concentrate Versus Platelet Transfusion

Abstract

Aim: Surgical treatment of patients with severe thrombocytopaenia (<50,000 platelets/mL) is a major problem for dentists due to an increased risk of bleeding. To reduce post-extraction haemorrhage, we tested a new approach using a platelet concentrate and compared its outcomes with those of routine platelet transfusion.

Methodology: Sixty-six patients with a platelet count between 29,000 and 46,000/mL were included in the study. Each patient was to undergo at least two sessions for the extraction of teeth; in one session the patients received a platelet transfusion before the extraction and in the other the post-alveolar sockets were treated with Plasma Rich in Growth Factors (PRGF). Patients were evaluated after 0.4, 1, 3 and 7 days to assess bleeding and haematoma.

Results: Patients treated with PRGF consistently exhibited a statistically significant reduction in post-extraction bleeding, hematoma and need for re-intervention. There is ample evidence that application of PRGF in the post-alveolar socket markedly reduced the risk of haemorrhage and associated complications in all patients.

Conclusion: PRGF concentrate is recommended for the treatment of thrombocytopaenic patients due to its remarkable ability to stimulate healing while greatly reducing side effects, such as bleeding and haematoma.

How to cite this article: Cocero N, Bergamasco L, Mozzati M. Oral Surgery In Severe Thrombocytopaenia Patients: A Case-Control Comparison of Platelet Concentrate Versus Platelet Transfusion. Int Dent Res 2012;2:33-36.

Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.