Biomechanic and biochemical analysis of the effects of local Ankaferd Blood Stopper® application on osseointegration of titanium implants

Erhan Cahit Özcan(1), Mehmet Gül(2), Abdulsamet Tanık(3), Tuba Talo Yıldırım(4), Mustafa Özkan(5), Alihan Bozoğlan(6), Hasan Emre Özdemir(7), Serkan Dündar(8)
(1) Firat University, Faculty of Medicine, Department of Esthetic, Plastic and Reconstructive Surgery, Elazığ, Turkey,
(2) Harran University, Faculty of Dentistry, Department of Periodontology, Şanlıurfa, Turkey,
(3) Adıyaman University, Faculty of Dentistry, Department of Periodontology, Adıyaman, Turkey,
(4) Firat University, Faculty of Dentistry, Department of Periodontology, Elazığ, Turkey,
(5) Hatay Mustafa Kemal University, Faculty of Medicine, Department of Esthetic, Plastic and Reconstructive Surgery, Hatay, Turkey,
(6) Firat University, Faculty of Dentistry, Department of Periodontology, Elazığ, Turkey,
(7) Firat University, Faculty of Medicine, Department of Esthetic, Plastic and Reconstructive Surgery, Elazığ, Turkey,
(8) Firat University, Faculty of Dentistry, Department of Periodontology, Elazığ, Turkey

Abstract

Aim: Investigations into Ankaferd Blood Stopper® (ABS) on bone healing have revealed positive bone regeneration effects. The exact mechanism of this positive bone tissue metabolism effect is unknown. This study’s aim is a biomechanic and biochemical investigation of the effects of local ABS application on the osseointegration of titanium implants.


Methodology: Sprague Dawley rats were divided into four groups of ten rats each. The control group (n=20) received no treatment during the experimental period, while the ABS group (n=20) had ABS applied locally during the surgical application of the titanium implant before insertion into the bone sockets. After 2 (controls n=10 and ABS n=10) and 4 weeks (controls n=10 and ABS n=10) experimental periods, the rats were sacrificed and implants with surrounding bone tissues were removed for reverse torque analysis (Newton), blood sample collection, and biochemical analysis.


Results: The biomechanic bone implant contact ratio detected was higher in week 4 than in week 2 in the ABS group (p<0, 05). Lower phosphor levels were detected in the ABS group than in the 4-week controls (p<0, 05).


Conclusion: According to the biomechanical parameters, ABS is more effective after four weeks than after two weeks when locally applied.


 


How to cite this article:


Özcan EC, Gül M, Tanık A, Yıldırım TT, Özkan M, Bozoğlan A, Özdemir HE, Dündar S. Biomechanic and biochemical analysis of the effects of local Ankaferd Blood Stopper® application on osseointegration of titanium implants. Int Dent Res 2022;12(1):27-33. https://doi.org/10.5577/intdentres.2022.vol12.no1.5


 


Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.

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Authors

Erhan Cahit Özcan
Mehmet Gül
Abdulsamet Tanık
samet.120a@gmail.com (Primary Contact)
Tuba Talo Yıldırım
Mustafa Özkan
Alihan Bozoğlan
Hasan Emre Özdemir
Serkan Dündar
Özcan, E. C., Gül, M., Tanık, A., Yıldırım, T. T., Özkan, M., Bozoğlan, A., Özdemir, H. E., & Dündar, S. (2022). Biomechanic and biochemical analysis of the effects of local Ankaferd Blood Stopper® application on osseointegration of titanium implants. International Dental Research, 12(1), 27-33. https://doi.org/10.5577/intdentres.2022.vol12.no1.5

Article Details

How to Cite

Özcan, E. C., Gül, M., Tanık, A., Yıldırım, T. T., Özkan, M., Bozoğlan, A., Özdemir, H. E., & Dündar, S. (2022). Biomechanic and biochemical analysis of the effects of local Ankaferd Blood Stopper® application on osseointegration of titanium implants. International Dental Research, 12(1), 27-33. https://doi.org/10.5577/intdentres.2022.vol12.no1.5
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