Protective effect of Melatonin and Ganoderma lucidum against the negative effects of extremely low frequency electric and magnetic fields in the periodontal tissues
Aim:The purpose of this study was to determine whether extremely low frequency electric and magnetic field (ELF-EMF) had any detrimental effects on periodontal tissue and to investigate, histologically and immunohistochemically whether melatonin (MLT) and Ganoderma lucidum (GL) had a protective role against these detrimental effects.
Methodology:A total of 56 adults, male Wistar Albino rats were used in this study. Rats were divided into 7 equal groups and exposed to ELF-EMF, which was produced by a high voltage source, 8 hours / day for 26 days. GL (20 mg / kg / day) and MLT (10 mg / kg / day) were administered by the oral gavage and intraperitoneal method.
Results: Fibrous degeneration in the periodontal membrane, inflammatory cell infiltration, connective tissue fiber organization, dilation, and hemorrhage in the blood vessels changes were determined in the periodontal tissue of the rats in groups I and IV. A statistically significant difference was determined in the groups treated with MLT and GL (p<0.05).
Conclusions: It has been determined that ELF-EMF exposure causes histological changes in the periodontal tissue of rats and that MLT and GL may protect against these effects.
How to cite this article: Gül M, Yavaş MC, Dündar S. Protective effect of Melatonin and Ganoderma lucidum against the negative effects of extremely low frequency electric and magnetic fields in the periodontal tissues. Int Dent Res 2019;9(3):119-26.
Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.
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